CircPPP1CB circular RNA suppresses tumorigenesis by interacting with the MiR-1307-3p / SMG1 axis in human bladder cancer
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Cell before Dev Biol. Sep 14, 2021; 9: 704683. doi: 10.3389 / fcell.2021.704683. Electronic collection 2021.
Circular RNA (circRNA) is a recently discovered endogenous non-coding RNA (ncRNA) characterized by a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as an object of study by circRNA sequencing and quantitative validation by real-time PCR (qRT-PCR) in bladder cancer (BC). CircPPP1CB is downregulated in British Columbia and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and the epithelial-mesenchymal transition (EMT) process in vitro and in vivo. Mechanically, we performed various experiments to verify the circPPP1CB / miR-1307-3p / SMG1 regulating axis. Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and the EMT process by interacting with the miR-1307-3p / SMG1 axis, and that circPPP1CB could be a novel therapeutic target and diagnostic biomarker in human BC.
PMID: 34595165 | PMC: PMC8476764 | DOI: 10.3389 / fcell.2021.704683